Indian Journal of Human Genetics
Home Current Issue Archives Guidelines Subscriptions e-Alerts Login 
Users online: 118
Print this page  Email this page Small font sizeDefault font sizeIncrease font size
BRIEF REPORT
Year : 2006  |  Volume : 12  |  Issue : 3  |  Page : 133-139

Chromosome 12;15 rearrangements in patients with recurrent miscarriage


CIMAR Genetics, Department of Fetomaternal Medicine, Edappal Hospitals, Kerala, India

Correspondence Address:
S B Nair
CIMAR Genetics, Department of Fetomaternal Medicine, Edappal Hospitals, Edappal, Malappuram, Kerala - 679 576
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.29857

Rights and Permissions

Background: An abnormal karyotype in either partner, especially featuring a translocation and/or inversion is considered to be a cause of recurrent miscarriages. It is generally assumed that recurrent miscarriage might be due to recurrent chromosomal abnormalities in the fetus due to a balanced aberration in one of the parents being inherited by the offspring in an unbalanced form. Aim: Evaluation of chromosomal rearrangements in couples with recurrent miscarriages. Materials and Methods: Peripheral blood was collected and lymphocyte cultures were set up. Slides prepared from the cell suspension were stained and screened for metaphases followed by karyotyping. Result: Balanced translocation was observed in the male partner in one case and in the female partners in the three other cases. Conclusion: Couples with recurrent miscarriage should be investigated for chromosomal rearrangements, thus helping in genetic counseling and providing the options for future pregnancies.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed11097    
    Printed206    
    Emailed1    
    PDF Downloaded362    
    Comments [Add]    

Recommend this journal