Indian Journal of Human Genetics
Home Current Issue Archives Guidelines Subscriptions e-Alerts Login 
Users online: 111
Print this page  Email this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2007  |  Volume : 13  |  Issue : 1  |  Page : 26-29

Impact of pericentric inversion of Chromosome 9 [inv (9) (p11q12)] on infertility


1 Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2 Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University; Department of Genetics, Royan Institute, Tehran, Iran
3 Department of Genetics, Royan Institute, Tehran, Iran

Correspondence Address:
Hossein Mozdarani
Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, P.O. Box 14115 - 111
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.32031

Rights and Permissions

Background : One of the frequent occurrences in chromosome rearrangements is pericentric inversion of the Chromosome 9; inv (9) (p11q12), which is consider to be the variant of normal karyotype. Although it seems not to correlate with abnormal phenotypes, there have been many controversial reports indicating that it may lead to abnormal clinical conditions such as infertility. The incidence is found to be about 1.98% in the general population. Materials and Methods : We investigated the karyotypes of 300 infertile couples (600 individuals) being referred to our infertility clinic using standard GTG banding for karyotype preparation. Results : The chromosomal analysis revealed a total of 15 (2.5%) inversions, among these, 14 male patients were inversion 9 carriers (4.69%) while one female patient was affected (0.33%). The incidence of inversion 9 in male patients is significantly higher than that of normal population and even than that of female patients (P<0.05). Conclusions : This result suggests that inversion 9 may often cause infertility in men due to spermatogenic disturbances, which are arisen by the loops or acentric fragments formed in meiosis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed17808    
    Printed280    
    Emailed4    
    PDF Downloaded564    
    Comments [Add]    
    Cited by others 10    

Recommend this journal