Indian Journal of Human Genetics
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Year : 2014  |  Volume : 20  |  Issue : 2  |  Page : 129-141

Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene, evolution, and immunity


1 School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India
2 Department of Zoology, Utkal University, Bhubaneswar, Odisha, India
3 Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, Odisha, India
4 Department of Medicine, University of Connecticut Health Center, Farmington, USA

Correspondence Address:
Ntiya G Chakraborty
Department of Medicine, University of Connecticut Health Center, Farmington
USA
Soma Chattopadhyay
Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, Odisha
India
Subhasis Chattopadhyay
School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha
India
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Source of Support: The work was partly supported by Department of Biotechnology, Ministry of Science and Technology, Govt. of India (Project no: T/PR13312/GBD/27/247/2009); (BT/PR13118/GBD/27/186/2009) and by Council of Scientific and Industrial Research (CSIR) Project No. 37 (1542)/12/EMR-II), Ministry of Science and Technology, Govt. of India,, Conflict of Interest: None


DOI: 10.4103/0971-6866.142855

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The evolutionary conserved, less-polymorphic, nonclassical major histocompatibility complex (MHC) class I molecules: Qa-1 and its human homologue human leukocyte antigen-E (HLA-E) along with HLA-F, G and H cross-talk with the T-cell receptors and also interact with natural killer T-cells and other lymphocytes. Moreover, these nonclassical MHC molecules are known to interact with CD94/NKG2 heterodimeric receptors to induce immune responses and immune regulations. This dual role of Qa-1/HLA-E in terms of innate and adaptive immunity makes them more interesting. This review highlights the new updates of the mammalian nonclassical MHC-I molecules in terms of their gene organization, evolutionary perspective and their role in immunity.


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